Metronidazole Benzoate
Introduction:
Metronidazole, a powerful antiprotozoal and antibacterial drug, has a bitter taste, and it is not acceptable to some young patients. Metronidazole benzoate (benzoyl Metronidazole), the benzoyl ester of metronidazole, is tasteless and has also been widely used because of its greater palatability. Metronidazole benzoate is the benzoate ester of metronidazole which is obtained by condensation of benzoic acid and metronidazole. It is hydrolyzed before or during absorption through the gut wall so that only metronidazole can be detected in the circulation.
General Applications:
Metronidazole benzoate is used in the treatment of infections in which anaerobic bacteria have been identified or are suspected as pathogens , particularly Bacteroides, Fragilis and other species of bacteroides and including other species for which metronidazole is bactericidal e.g. Fusobacteria, Eubacteria, Clostridia and anaerobic Cocci. It can be used in septicaemia, bacteraemia, brain abscess, peritonitis and post-operative wound infectiondue to anaerobic bacteria. Itis used also in prevention of acute dental infections (e.g. acute pericoronitis and acute apical infections), Trichomonas infections, Amoebiasis and Giardiasis...
