Delta-sleep-inducing peptide (DSIP, other name: Emideltide; DSIP nonapeptide; Deltaran) is a naturally occurring short peptide with various physiological and endocrine functions. Its name derives from its ability to induce sleep in rabbits and its initial discovery in 1977 from rat brains during slow-wave sleep. As researchers continue to explore DSIP, they are uncovering its diverse roles. Currently, it is known that DSIP can modulate corticotropin levels, inhibit somatostatin secretion, reduce stress, normalize blood pressure, regulate sleep patterns, and influence pain perception. Moreover, DSIP holds potential for future applications in cancer treatment, depression management, and prevention of free radical damage.
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What are the benefits of DSIP?
The benefits of DSIP (Delta-sleep-inducing Peptide) are wide-ranging and diverse, as supported by scientific research. Some of the notable benefits and roles of DSIP include:
❶ Sleep Promotion. DSIP is a sleep-promoting substance that can help improve sleep quality and duration. It has a modulating effect on sleep and wake functions, making it particularly effective in circumstances where sleep is disturbed..[9][10]
❷ Stress Reduction. DSIP acts as a stress-limiting factor and exhibits anti-stress properties, helping to alleviate stress-induced metabolic and functional disorders.
❸ Endocrine Regulation. DSIP affects various hormonal levels, including decreasing basal corticotropin levels and blocking its release, stimulating luteinizing hormone (LH) secretion, and affecting somatoliberin and somatotrophin secretion.
❹ Neuroprotective Effects. DSIP has demonstrated neuroprotective properties, protecting the brain from various insults and potential damage.
❺ Antioxidant Properties. DSIP has been shown to enhance oxidative phosphorylation in rat mitochondria, suggesting potential antioxidant effects..
❻ Geroprotective Effects. DSIP has been found to have geroprotective effects, slowing down age-related changes and contributing to increased maximum life span in certain studies.
Additionall, DSIP has been found to have several other physiological effects.
❶ Potential for Addiction and Withdrawal Treatment. DSIP may act antagonistically on opiate receptors, inhibiting the development of opioid and alcohol dependence and showing promise in clinical trials for treating withdrawal syndromes.
❷ Immune Function. DSIP may play a role in immune function, though further research is needed to fully understand its impact..
❸ Potential Therapeutic Applications. DSIP has been investigated for its use in various medical conditions, including narcolepsy, chronic pain, major depressive disorder, Alzheimers disease, and central nervous system function in children after antiblastomic therapy.
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